Johnson & Johnson and Bayer’s legacy blood thinner Xarelto has had a tough year with competitors picking up steam and prescriptions leveling off. But in a hard-to-treat artery disease, the drug just posted a new trial in recent post-surgery patients.
A combination of Xarelto and aspirin reduced the risk of major limb and cardiovascular events by 15% over aspirin alone in symptomatic peripheral artery disease (PAD) patients who had recently undergone surgery to unblock arteries in their legs, according to data presented Saturday at the American College of Cardiology scientific sessions.
At 28 weeks of treatment, 17.3% of patients treated with a Xarelto-aspirin combo suffered acute limb ischemia, major amputation for vascular cause, heart attack, ischemic stroke or cardiovascular death compared with 19.9% in the solo aspirin arm.
The study also showed that while patients treated with Xarelto showed higher rates of bleeding, there wasn’t a higher rate of severe bleeding events in the Xarelto arm, including intracranial or fatal bleeds.
Xarelto, which received a FDA nod in October 2018 to reduce the risk of cardiovascular events in PAD patients, has faced an uphill climb against high-performing blood thinners like Pfizer and Bristol Myers Squibb’s Eliquis, which has taken the market by storm in recent years after a slow initial launch.
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